Work in the Klengel Lab focuses on the underlying molecular mechanisms of neuropsychiatric diseases and towards the development of novel preventive and therapeutic approaches.
Psychiatric disorders are highly prevalent; yet, our understanding of the underlying molecular mechanisms leading to the development of these devastating disorders is unfortunately scarce. As a consequence, we also currently lack effective preventive and therapeutic strategies, which leads to an enormous burden for individuals, families, and our societies. The goal of our group is to contribute to a better understanding of psychiatric diseases and thus better interventions. Pursuing a translational approach, we integrate clinically derived data sets and samples, animal models and a diverse set of molecular approaches to identify factors contributing on the molecular level to risk or resilience for psychiatric diseases.
Melanie Bückner, Research Assistant (Together with Boretius Lab)
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If you are interested in working with us, please contact us. We are always looking for curious and motivated researchers.
PGC-PTSD GWAS paper published
The Psychiatric Genomics Consortium published a GWAS on PTSD including over 30,000 PTSD cases and 170,000 controls. Lead by the labs of Caroline Nievergelt, Karestan Koenen, Israel Liberzon and Kerry Ressler, this study shows that risk for PTSD after a traumatic event is partially heritable with a significant shared liability between PTSD and other psychiatric disorders. Notably, this study included individuals from diverse ethnic groups and suggest that the genetic risk for disease may be ancestry-specific. This is the bioRxiv link.