Work in the Klengel Lab focuses on the underlying molecular mechanisms of neuropsychiatric diseases and towards the development of novel preventive and therapeutic approaches.
Psychiatric disorders are highly prevalent; yet, our understanding of the underlying molecular mechanisms leading to the development of these devastating disorders is unfortunately scarce. As a consequence, we also currently lack effective preventive and therapeutic strategies, which leads to an enormous burden for individuals, families, and our societies. The goal of our group is to contribute to a better understanding of psychiatric diseases and thus better interventions. Pursuing a translational approach, we integrate clinically derived data sets and samples, animal models and a diverse set of molecular approaches to identify factors contributing on the molecular level to risk or resilience for psychiatric diseases.
Giovanie Yacorps, Undergraduate Researcher
Lakshmi Haferman, BSc - Research Assistant (Together with Sabina Berretta)
Sharvari Narendra, MSc - Undergraduate Researcher (Together with Jung Suh and Kerry Ressler)
Melanie Bückner, MSc - Research Assistant (Together with Susann Boretius)
You are interested in Neurobiology, Psychiatric Disorders, and Molecular Biology? - Become a Lab Member!
If you are interested in working with us, please contact us. We are always looking for curious and motivated researchers.
PGC-PTSD GWAS paper published
The Psychiatric Genomics Consortium published a GWAS on PTSD including over 30,000 PTSD cases and 170,000 controls. Lead by the labs of Caroline Nievergelt, Karestan Koenen, Israel Liberzon and Kerry Ressler, this study shows that risk for PTSD after a traumatic event is partially heritable with a significant shared liability between PTSD and other psychiatric disorders. Notably, this study included individuals from diverse ethnic groups and suggest that the genetic risk for disease may be ancestry-specific. This is the bioRxiv link.
Effects of Infant Maltreatment across Generations in Monkeys
In collaboration with Mar Sanchez’ lab at the Yerkes National Primate Center at Emory University, we published a paper on the effects of infant maltreatment in rhesus monkeys on epigenetic programming across generations. Maltreatment in mothers leads to functional DNA methylation changes in FKBP5 in offspring even when they were raised by foster mothers providing evidence for intergenerational effects of maltreatment on epigenetic programming in non-human primates. This is the bioRxiv link.
Lucy Allbaugh | University of Dayton
Sabina Berretta | McLean Hospital | Harvard Medical School
Elisabeth Binder | Max Planck Institute of Psychiatry
Susann Boretius | German Primate Center | University of Göttingen
Gregory Quirk | University of Puerto Rico School of Medicine
Kerry Ressler | McLean Hospital | Harvard Medical School
Mar Sanchez | Yerkes National Primate Center | Emory University
Martin Teicher | McLean Hospital | Harvard Medical School